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严琼姣

来源:中文版十博手机网址 发布时间:2019.05.24 16:34
  
  姓名严琼姣
  性别:
  出生年月:1974年12月
  学历/学位:博士
  职称:副研究员
  联系电话:13554109658
  Email:yanqiongjiao2@126.com
  

  教育经历:

  2005 -- 2008中文版十博手机网址生物材料学,  博士   

  1996 -- 1999, 武汉工程大学化学工艺专业, 硕士   

   1992 -- 1996, 武汉工程大学化学制药专业, 学士

  研究经历:

  2016 -- 现在, 中文版十博手机网址十博制药工程系,       副研究员 

  2016 -- 2017, 美国得州大学圣安东尼奥健康科学中心,     访问学者 

  2009 -- 2016, 中文版十博手机网址生物材料与工程研究中心,     副研究员 

  1999 -- 2005, 武汉工程大学化工与制药学院,          工程师
  
  研究领域:

  药物新剂型与新技术、药物的合成及工艺研究、生物医用高分子材料

  代表性科研项目:

  主持的科研项目

  2014 -- 2015,湖北省知识产权局《RGD多肽接枝复合材料及其制备方法》

  2011 -- 2012,国家知识产权局《RGD多肽接枝复合材料及其制备方法》

  2013 -- 2014,校自主创新基金《生物活性PRGD/VPA/BMSCs人工神经的研究》

  2010 -- 2011,校自主创新基金《PRGD/PLA/NGF脊髓修复材料的制备及性能研究》

  参与的主要科研项目

  2018 -- 2021,国家科技部国家重点研发计划项目《适用于增材制造的可降解医用高分子及其复合材料研究》

  2018 -- 2021,国家科技部国家重点研发计划项目《适用于增材制造的可降解生物无机及其复合材料》

  2016 -- 2020,国家科技部国家重点研发计划项目《诱导型纳米复合材料神经移植物研发》

  2015 -- 2018,国家科技部国际合作项目《生物活性神经再生诱导材料关键技术合作研究》

  2013 -- 2015,国家教育部科学技术研究重大项目《仿生周围神经修复材料制备、降解特性及神经诱导作用研究》

  2011 -- 2015,国家“973”课题《材料诱发组织形成的信号转导机制》

  2006 -- 2010,国家“973”课题《自组装生物材料及其诱导神经组织生长的机理》

  代表性论文与专著

  [1] Jiling Yi, Nan Jiang, Binbin Li, Qiongjiao Yan, Tong Qiu, K. Swaminathan Iyer, Yixia Yin, Honglian Dai, Ali K. Yetisen, Shipu Li. Painful Terminal Neuroma Prevention by Capping PRGD/PDLLA Conduit in Rat Sciatic Nerves. Advanced Science, 2018, 5, 1700876. (SCI)

 

  [2] Wei Xu, Chao Xu, Qiongjiao Yan, Honglian Dai. The effect of different hydroxyapatite microparticles on osteogenic differentiation of MC3T3-E1 preosteoblasts, Journal of  Materials Chemistry B, 2018,6:5234-5242. (SCI)

  [3] Nan Jiang, Yong Wang, YiXia Yin, Ruipeng Wei, Guoliang Ying, Binbin Li, Tong Qiu, Patrick Rijn, Ge Tian, Qiongjiao Yan, Honglian Dai, Henk J Busscher, Shipu Li, Ali K Yetisen, XiaoYu Yang. bFGF and Poly-RGD Cooperatively Establish Biointerface for Stem Cell Adhesion, Proliferation and Differentiation. Advanced Materials Interfaces, 2018, 1700702. (SCI)

  [4] Li BinBin, Qiu Tong, Lyer K.S., Yan QiongJiao, Yin YiXia, Xie LiJuan, Wang XinYu, Li ShiPu. PRGD/PDLLA conduit potentiates rat sciatic nerve regeneration and the underlying molecular mechanism. Biomaterials, 2015,55:44-53. (SCI)

  [5] Yin Yixia, Li Binbin, Yan Qiongjiao, Dai Honglian, Wang Xinyu, Huang Jifeng, Li Shipu. Promotion of peripheral nerve regeneration and prevention of neuroma formation by PRGD/PDLLA/β-TCP conduit: report of two cases. Regenerative Biomaterials, 2015, 2(2): 119-124.

  [6] Yixia Yin, Jiling Yi, Lijuan Xie, Qiongjiao Yan, Honglian Dai, Shipu Li*. Synthesis, characterization and biological evaluation of poly [LA-co-(Glc-alt-Lys)] for nerve regeneration scaffold. Front. Mater. Sci., 2014, 8(1): 95-101. (SCI)

  [7] Qiu Tong, Yin YiXia, Li BinBin, Xie LiJuan, Yan QiongJiao, Dai HongLian, Wang XinYu, Li ShiPu. PDLLA/PRGD/β-TCP conduits build the neurotrophin-rich microenvironment suppressing the oxidative stress and promoting the sciatic nerve regeneration.  Journal of Biomedical Materials Research Part A, 2014,102:3734-3743. (SCI)

  [8] Jifeng Huang, Jie Xiang, Qiongjiao Yan*, Shipu Li, Lantang Song, Xianhua Cai. Dog tibial nerve regeneration across a 30-mm defect bridged by a PRGD/PDLLA/β-TCP/NGF sustained-release conduit. Journal of Reconstructive Microsurgery, 2013, 29(02):77-88. (SCI)

  [9] Qiu Tong, Yu Chang, Yan QiongJiao, Li ShiPu. Degradable PRGD/PDLLA/β-TCP/NGF composites promote differentiation and regulate gene expression in rat pheochromocytoma cells. Chinese Science Bulletin, 2013,58: 2979-2983. (SCI)

  [10] Yan Qiongjiao, Yin Yixia, Li Binbin. Use new PLGL-RGD-NGF nerve conduits for promoting peripheral nerve regeneration. Biomedical Engineering Online, 2012, doi:10.1186/1475-925X-11-36. (SCI)

  [11] Yin Yixia, Yan Qiongjiao, Yan Yuhua, Chen Xiaoming, Li Shipu*, In vitro biocompatibility assessment of a novel PRGD/PDLLA/NGF composite material. Journal of Wuhan University of Technology-Materials Science Edition, 2011,26(6):1059-1063. (SCI)

  [12] Huang Jifeng, Li Dezhong, Yan Qiongjiao*, Zheng Huayong, Li Shipu. Evaluation of PRGD/FK506/NGF conduits for peripheral nerve regeneration in rats. Neurology India, 2010, 58 (3):384-391. (SCI)

  [13] Qiongjiao Yan, Juan Li, Shipu Li, Yixia Yin,Ping Zhang. Synthesis and RGD peptide modification of poly{(lactic acid)-co-[(glycolic acid)-alt-(L-lysine)]}. E-Polymers, 2008, no. 028:1~12. (SCI)

  [14] 陈芬儿,严琼姣, 刘明星, 邵兰英, 户业丽,洛索洛芬钠合成工艺研究Ⅱ.高区域选择性烷基化合成法,中国医药工业杂志,2000, 31(1): 1-2.

  [15] 陈芬儿,严琼姣,彭作中,张道明,傅晗,刘继东,四正丁基过硫酸铵氧化裂解2,4 —二硝基苯腙衍生物的反应研究,有机化学,2000, 20(1): 116-121.

  [16] 陈芬儿,严琼姣,邵兰英,刘明星,D296树脂分散钯催化氢转移反应的研究Ⅰ.取代芳香硝基化合物的还原,离子交换与吸附,1999, 15(6): 572-576.

  [17] 陈芬儿,李麟,冯秀梅,户业丽,张洪元,严琼姣,dl-萘普生重排合成的工艺研究Ⅵ,中国医药工业杂志,1997, 28(11): 483-486.

  [18] 有机药物合成法(第一卷),中国医药科技出版社,1999.4,  编委

 

  代表性专利

  [1] 李世普, 韩颖超, 闫玉华, 万涛, 王欣宇, 袁琳, 戴红莲, 严琼姣,RGD多肽接枝聚(羟基乙酸-L-赖氨酸-L-乳酸)/ β-磷酸三钙复合材料及其制备方法,中国发明专利,授权专利号:ZL 200610019493.9.

 

  [2] Li Shipu, Han Yingchao, Yan YuHua, Wan Tao, Wang Xinyu, Yuan Lin, Dai Honglian, Yan Qiongjiao, RGD peptide grafted poly(glycolic acid-L-lysine-L-lactic acid)/β-tricalcium phosphate composite material and preparation method thereof, 美国发明专利,授权专利号: US 7,989,532 B2.

  [3] Li Shipu, Han Yingchao, Yan YuHua, Wan Tao, Wang Xinyu, Yuan Lin, Dai Honglian, Yan Qiongjiao, RGD peptide grafted poly(glycolic acid-L-lysine-L-lactic acid)/tricalcium phosphate composite material and preparation method thereof, 欧洲发明专利,授权专利号:EP 2039 377B1.

  奖励

  [1]建筑材料科学技术奖(技术发明类),一等奖,第四完成人,2014 

   [2]军队科学技术进步二等奖,第五完成人,2017 

 

  

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